U.S., July 24 -- ClinicalTrials.gov registry received information related to the study (NCT07081087) titled 'Replacing Bone Marrow With Peripheral Blood in Cytopenia Patients' on July 15.
Brief Summary: This study aims to validate a novel, non-invasive diagnostic approach for blood and bone marrow malignancies using single-cell RNA sequencing of circulating hematopoietic stem and progenitor cells (cHSPCs) from peripheral blood. Building on prior work defining normal cHSPC profiles in healthy individuals, the study introduces a pipeline for identifying blood pathologies, with a focus on improving the diagnosis and subclassification of myelodysplastic syndromes (MDS). A multi-center clinical trial is proposed to evaluate the method's ability...