Clinical Trial: Randomized Crossover Study in Adults Using Clear Aligners: Effects of Brushing, Chlorhexidine Mouthwash, and an Oxygen-Based Cleanser on Oral Microbial Ecology and Periodontal Indices

U.S., Dec. 30 -- ClinicalTrials.gov registry received information related to the study (NCT07307716) titled 'Randomized Crossover Study in Adults Using Clear Aligners: Effects of Brushing, Chlorhexidine Mouthwash, and an Oxygen-Based Cleanser on Oral Microbial Ecology and Periodontal Indices' on Dec. 15.

Brief Summary: This randomized crossover study will assess how three aligner-cleaning methods affect early supragingival oral microbial ecology and periodontal health in adults using clear aligners. Each participant will complete three (1-month) periods in a randomized sequence with (1-week) washouts between periods:

1. Mechanical toothbrushing with fluoride toothpaste (control),

2. Chlorhexidine (CHX) mouthwash, and

3. an oxygen-based ...