U.S., Feb. 6 -- ClinicalTrials.gov registry received information related to the study (NCT06810310) titled 'Psilocybin on Brain Mechanisms of Motivation in OUD' on Jan. 30.
Brief Summary: The goal of this study is to test addiction-related brain circuitry (motivation/reward and inhibition) as well as neurocognitive circuitry prior to and following low or high dose psilocybin (PEX010 from Filament). Using fMRI, we will examine brain circuits relevant to drug relapse as well as neurocognitive flexibility circuits in individuals with opioid use disorder.
We will randomize 24 males and females, aged 18 - 60, in the greater Philadelphia area, to either 1mg or 25 mg of psilocybin. Participants will
1. come to our offices for screening visits -...