U.S., June 19 -- ClinicalTrials.gov registry received information related to the study (NCT07026552) titled 'Proteomic and Histological Analysis of Ligamentum Flavum in Lumbar Stenosis' on March 07.
Brief Summary: Background Lumbar spinal stenosis (LSS) is a common condition characterized by spinal canal narrowing, often linked to ligamentum flavum hypertrophy (LFH) and degeneration. Fibrotic processes involving elastin and collagen alterations contribute to LF thickening and spinal instability. Despite progress, the molecular mechanisms underlying LFH remain unclear, necessitating targeted diagnostic and therapeutic strategies.
Objective This study aims to analyze the proteomic and histological changes in LFH associated with LSS, correla...