Clinical Trial: Project COMET: Massed Prolonged Exposure for PTSD and SUD

U.S., May 14 -- ClinicalTrials.gov registry received information related to the study (NCT06968832) titled 'Project COMET: Massed Prolonged Exposure for PTSD and SUD' on April 28.

Brief Summary: The goal of this clinical trial is to learn if Massed Prolonged Exposure Therapy (M-PE) can improve PTSD symptoms and reduce substance use in adults receiving intensive outpatient (IOP) treatment for substance use disorder (SUD). The main questions it aims to answer are:

* Does M-PE reduce PTSD symptoms more effectively than trauma treatment as usual (TAU)?

* Does M-PE reduce the number of days participants use substances?

* How do patient-centered outcomes (such as depression, suicidal thoughts, and quality of life) differ between M-PE and trau...