U.S., Dec. 9 -- ClinicalTrials.gov registry received information related to the study (NCT07270978) titled 'Phase Ib Study of CD33 FPBMC in Patients With MRD+ AML or MDS' on Nov. 17.
Brief Summary: The purpose of this study is to understand the safety and estimate the efficacy of combining anti-CD3 x anti-CD33 bispecific antibody (CD33Bi) armed fresh peripheral blood mononuclear cells (CD33Bi FPBMC) for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) where they still have detectable disease ("MRD+") after some treatment. Participants receive 4 weekly doses of CD33 FPBMC by intravenous infusion followed by 4-6 weeks of standard treatment with a hypomethylating agent (type of treatment such as decitabine or azaci...