U.S., Jan. 29 -- ClinicalTrials.gov registry received information related to the study (NCT06795581) titled 'PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder' on Jan. 25.
Brief Summary: Background:
People with alcohol use disorder (AUD) also often have bouts of depression called major depressive episodes (MDEs). People having MDEs have been found to have low levels of a protein called PDE4B in the brain. Researchers want to find out if people with AUD also have low levels of PDE4B. This research may help lead to better treatments for AUD.
Objective:
To find out (1) if PDE4B levels are lower in people who are withdrawing from AUD and (2) if their PDE4B levels go up after they abstain from alcohol for 3 to 4 weeks.
Eli...