Clinical Trial: PEEP-induced Effects on Respiratory dRivE and EFfort

U.S., Oct. 3 -- ClinicalTrials.gov registry received information related to the study (NCT07203781) titled 'PEEP-induced Effects on Respiratory dRivE and EFfort' on Sept. 04.

Brief Summary: Rationale:

In patients with acute hypoxemic respiratory failure (AHRF), preserving spontaneous breathing during mechanical ventilation offers physiological benefits, but also carries risks. While spontaneous breathing improves gas exchange and limits diaphragm atrophy, strong inspiratory efforts may worsen lung and diaphragm injury. Balancing these factors requires refined and tailored strategies, such as the modulation of PEEP. However, the impact of PEEP on neural respiratory drive and inspiratory effort is very heterogenous, and these two entities h...