U.S., Nov. 27 -- ClinicalTrials.gov registry received information related to the study (NCT07251816) titled 'Neural Bases of Motivation' on Sept. 01.
Brief Summary: Effort-based decisions are essential in daily life but strongly impaired in apathy across various brain disorders. Now, significant research to unveil the neural causes of apathy is needed. A crucial corollary to this is the need to identify the brain network and neural mechanisms underlying effort-based decisions.
A fronto-striatal network and the noradrenergic system are involved in effort-based decision-making and apathy. Further, motor cortical structures may play a role in effort-based decision-making. However, the role of circuits connecting the fronto-striatal network a...