U.S., Nov. 27 -- ClinicalTrials.gov registry received information related to the study (NCT07252557) titled 'Mouthwash Temperature and Oral Mucositis in Head and Neck Radiotherapy' on Nov. 18.
Brief Summary: This single-center randomized controlled trial evaluates the effects of cold (15-20degC) versus room-temperature (30-35degC) water gargling on oral mucositis severity, pain, and comfort in patients with head and neck cancer undergoing radiotherapy. Participants will rinse their mouth four times daily for 30-60 seconds over a 6-week radiotherapy course, with follow-up for two additional weeks. The study hypothesizes that cold-water rinsing can reduce the severity of radiation-induced oral mucositis (RTOM) and pain, improve oral comfort,...