U.S., Dec. 3 -- ClinicalTrials.gov registry received information related to the study (NCT07259291) titled 'Minto and Eleveld Remifentanil Target Controlled Infusion (TCI) Models: a Clinical Comparison' on Sept. 29.
Brief Summary: Remifentanil is commonly used as an opioid during general anesthesia. In recent years, several pharmacokinetic/pharmacodynamic (PK/PD) models for target-controlled infusion (TCI) have been developed, with the Eleveld model being one of the most recent and designed for broad applicability.
The aim of this study is to compare the Eleveld TCI model with the routinely used Minto model, in order to evaluate potential differences in the predicted effect-site concentrations (CeR) required to achieve equivalent analgesi...