U.S., Jan. 9 -- ClinicalTrials.gov registry received information related to the study (NCT07324954) titled 'Methylene Blue in Total Knee Arthroplasty (TKA)' on Dec. 23, 2025.
Brief Summary: The purpose of this pilot study is to determine the volume of irrigation required to achieve macroscopic clearance of contaminants during a debridement, antibiotics, and implant retention (DAIR) procedure for periprosthetic joint infection (PJI) of the knee. Given the lack of robust data guiding irrigation volume in this setting, the investigator proposes to use the application of methylene blue dye intraoperatively to simulate contaminant presence. Serial irrigation will be performed, with photographic documentation taken every 2,000mL until visible dy...