U.S., Dec. 10 -- ClinicalTrials.gov registry received information related to the study (NCT07272967) titled 'Metformin in Preventing Secondary Gliosis Following Acute Thoraco-Lumbar Spinal Cord Injury' on Nov. 19.
Brief Summary: Background:
Spinal cord injury (SCI) is a major global health problem, with thoraco-lumbar injuries often leading to paraplegia and incomplete neurological recovery. The glial scar, resulting from astrocyte activation at the injury site, constitutes a major barrier to axon regeneration. Given the limitations of current treatments, there is an urgent need for new interventions to improve outcomes. Metformin, a common drug for diabetes, shows promising potential as a neuroprotective agent in preclinical SCI models, ...