U.S., Dec. 20 -- ClinicalTrials.gov registry received information related to the study (NCT07294469) titled 'Menthol for Improving Movement and Sleep in Parkinson's Disease Patients' on Dec. 08.
Brief Summary: Parkinson's disease (PD) is a progressive neurological disorder characterized by both motor and non-motor symptoms due to the degeneration of dopamine-producing neurons. There is currently no cure. Menthol, a natural compound that activates TRPM8 receptors, has shown neuroprotective and motor function benefits in preclinical PD models. In mice, distal limb immersion in menthol improved dopamine neuron survival and motor performance. Similar menthol-based interventions improved outcomes in a stroke model and a clinical trial with stro...