U.S., May 3 -- ClinicalTrials.gov registry received information related to the study (NCT06955130) titled 'Lactate and Glycerol Contribution to Gluconeogenesis' on April 24.
Brief Summary: A major cause of increased blood glucose levels in type 2 diabetes (T2D) is increased hepatic gluconeogenesis (GNG), as the liver converts various substrates into glucose. Two of these substrates include glycerol, a molecule from fat, and lactate, a molecule that circulates in the blood. Our previously collected data suggest that glycerol's role in this process has been underestimated, so we will directly compare the carbon contribution of glycerol and lactate to new glucose production under fasting conditions in patients with and without T2D. We will al...