Clinical Trial: Investigation of Vancomycin Efficacy in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis

U.S., Jan. 15 -- ClinicalTrials.gov registry received information related to the study (NCT07341282) titled 'Investigation of Vancomycin Efficacy in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis' on Dec. 02, 2025.

Brief Summary: This clinical trial tests if oral vancomycin can safely treat active ulcerative colitis (UC) in adults who also have primary sclerosing cholangitis (PSC), a liver condition. The main questions it aims to answer are:

* Can oral vancomycin improve UC symptoms as measured by Mayo score at 4 weeks?

* Is oral vancomycin safe and tolerable in this patient group?

Participants will be compared to see if vancomycin works better than placebo. Participants will:

* Take oral vancomycin (250 mg twice d...