U.S., July 24 -- ClinicalTrials.gov registry received information related to the study (NCT07081594) titled 'Investigating the Impact of Sex Hormones in Multiple Sclerosis' on June 17.
Brief Summary: Emerging evidence indicates that females with MS experience worsened symptoms during the luteal phase (post ovulation) of the menstrual cycle when progesterone levels rise and estradiol fluctuate. The rapid hormonal swings may disrupt hypothalamic regulation, leading to an increase in body temperature - a well-established trigger for MS symptom exacerbation. These hormonal changes could also affect neuromuscular function, as estradiol and progesterone receptors are present in the nervous system and skeletal muscles.
Three critical aspects of ...