U.S., March 1 -- ClinicalTrials.gov registry received information related to the study (NCT06853340) titled 'Impact of Vascular Calcification and CASR Expression by Monocytes in Septic Shock' on Feb. 25.
Brief Summary: In septic shock, bacterial LPS is able to activate the CaSR of cardiomyocytes inducing their apoptosis in vitro. CaSR activation in monocytes is responsible for activation of the NLRP3 inflammasome and macropinocytosis. In front of this immune axis, a variation in the monocyte expression of the CaSR is expected in the state of shock. This is already observed in other pathologies such as renal failure or in animal models of severe burns. If this is considered as an overall reflection of CaSR expression in the body, it would b...