Clinical Trial: Impact of NMN Supplementation on CD4+ T Cell Recovery in HIV Patients With Immunological Failure

U.S., March 22 -- ClinicalTrials.gov registry received information related to the study (NCT06889142) titled 'Impact of NMN Supplementation on CD4+ T Cell Recovery in HIV Patients With Immunological Failure' on March 03.

Brief Summary: This proof-of-concept study aims to investigate the potential impact of supplementing with Nicotinamide Mononucleotide (NMN), a direct precursor of NAD+ on CD4+ T cell recovery in virologically suppressed HIV patients experiencing immunological failure on ART. We hypothesize that NMN supplementation will increase intracellular NAD+ levels, thereby improving CD4+ T cell function and potentially reversing immunological failure. A small cohort of patients will be recruited to evaluate the primary outcome of cha...