U.S., May 1 -- ClinicalTrials.gov registry received information related to the study (NCT06951477) titled 'Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty' on April 07.
Brief Summary: Many patients who receive knee replacement surgery must return for a revision (or repeat) surgery due to ongoing pain, stiffness, infection, or implant loosening. The role of the gut microbiome-the collection of bacteria and other microbes within the human gastrointestinal tract-is just beginning to be recognized in orthopaedics. The gut microbiome has been found to affect the immune response and bone regulation, potentially contributing to infection or loosening after total joint replacement. Antibiotics are regularly used in orthopaedic sur...