U.S., Aug. 27 -- ClinicalTrials.gov registry received information related to the study (NCT07142317) titled 'GPR146 and Cholesterol Metabolism' on Aug. 19.
Brief Summary: Blood cholesterol balance is regulated by an interplay between the small intestine and the liver. Recently, a new protein (cholesin) was discovered, which is secreted by intestinal cells after dietary cholesterol intake. Cholesin travels to the liver and binds to the GPR146 receptor. This inhibits cholesterol production in the liver. Because plant sterols lower blood cholesterol levels by reducing cholesterol absorption in the intestine, we would like to understand the effects of plant sterols on GPR146. Our hypothesis is that the production of the GPR146 gene differs aft...