U.S., Nov. 11 -- ClinicalTrials.gov registry received information related to the study (NCT07226440) titled 'Examining a Novel Gastrointestinal Intervention to Negate Environmental Toxicants (ENGINE)' on Nov. 06.
Brief Summary: This randomized, placebo-controlled crossover trial will test the feasibility and acceptability of using colesevelam in male firefighters with high per- and polyfluoroalkyl substances (PFAS) exposure. This trial will also explore whether colesevelam lowers blood PFAS levels and urine environmental toxicant and mold mycotoxin levels.
Study Start Date: Dec., 2025
Study Type: INTERVENTIONAL
Condition:
Toxicant Exposure
Firefighter
Occupational Exposure to Chemicals
Intervention:
DRUG: Colesevelam
We will provide...