U.S., May 7 -- ClinicalTrials.gov registry received information related to the study (NCT06958809) titled 'Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock Patients' on April 09.
Brief Summary: Septic shock remains a leading cause of mortality in intensive care, and while fluid resuscitation (FR) is a cornerstone of early management, its benefit-risk balance is highly variable. Excessive fluid administration can cause venous congestion and organ dysfunction, while insufficient resuscitation risks hypoperfusion. Current strategies often rely on fluid responsiveness (i.e., increased cardiac output after fluids), but this does not guarantee improved outcomes, particularly if congestion ensues.
This...