U.S., Jan. 13 -- ClinicalTrials.gov registry received information related to the study (NCT07331727) titled 'Epicardial Adipose Tissue-Targeted DApagliflozin for Reducing Electrical Remodeling in Atrial Fibrillation' on Dec. 29, 2025.
Brief Summary: Persistent atrial fibrillation (PeAF) is associated with a high risk of recurrence following catheter ablation despite advances in ablation technology and strategies. Beyond electrophysiological mechanisms, increasing evidence suggests that atrial structural and inflammatory remodeling plays a pivotal role in the initiation and maintenance of AF, particularly in persistent forms.
Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot located between the myocardium and vis...