Clinical Trial: Efficacy and Safety of Esomeprazole 40 mg IV in Post-Surgical Patients Admitted to the ICU

U.S., Feb. 11 -- ClinicalTrials.gov registry received information related to the study (NCT07399054) titled 'Efficacy and Safety of Esomeprazole 40 mg IV in Post-Surgical Patients Admitted to the ICU' on Dec. 26, 2025.

Brief Summary: Critically ill patients admitted to intensive care units (ICUs) are predisposed to upper gastrointestinal (GI) bleeding secondary to stress-related mucosal damage. The two most significant independent risk factors for stress ulceration and subsequent GI bleeding in this setting are mechanical ventilation and coagulopathy.1,2 Observational data indicate that proton pump inhibitors (PPIs) remain the most frequently employed prophylactic agents in the ICU.3

Comparative studies evaluating the efficacy of PPIs hav...