Clinical Trial: Efficacy and Safety of Entacapone Combined With Madopar in the Treatment of Early Parkinson's Disease (PD): A Prospective, Multicenter, Non-Randomized Controlled Study

U.S., April 16 -- ClinicalTrials.gov registry received information related to the study (NCT06928519) titled 'Efficacy and Safety of Entacapone Combined With Madopar in the Treatment of Early Parkinson's Disease (PD): A Prospective, Multicenter, Non-Randomized Controlled Study' on March 22.

Brief Summary: This study aims to evaluate the efficacy and safety of combining entacapone with Madopar (levodopa/benserazide) in the treatment of early-stage Parkinson's disease (PD). Levodopa is the most effective medication for PD, but long-term use often causes motor complications due to its short half-life. Entacapone is a COMT inhibitor that can prolong levodopa's effect and stabilize its blood levels.

This prospective, multicenter, non-randomize...