U.S., Feb. 1 -- ClinicalTrials.gov registry received information related to the study (NCT06803485) titled 'Effect of Venlafaxine Versus Dosulepin in Pain Predominant Somatic Symptom Disorder' on Jan. 27.
Brief Summary: Somatic symptom disorder (SSD) is marked by persistent physical complaints, often involving pain, alongside excessive thoughts or behaviors related to health, which substantially disrupt daily functioning. The underlying mechanisms of SSD are multifaceted. The serotonin hypothesis links low serotonin levels to the development of somatic symptoms, while the cortisol hypothesis highlights dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, with chronic stress often associated with hypocortisolism. Furthermore, the...