Clinical Trial: Effect of N-acetylcysteine as Adjunct Therapy on the Clinical Outcome of Neonatal Sepsis

U.S., Feb. 3 -- ClinicalTrials.gov registry received information related to the study (NCT07380347) titled 'Effect of N-acetylcysteine as Adjunct Therapy on the Clinical Outcome of Neonatal Sepsis' on Dec. 20, 2025.

Brief Summary: Neonatal sepsis (NS) is a life-threatening condition characterized by systemic inflammation in response to infection during the first 28 days of life. Nowadays, it is generally acknowledged that one of the critical pathogenic mechanisms involved in neonatal sepsis is oxidative stress, which plays a critical role in amplifying inflammation and cellular injury. During sepsis, activated immune cells such as neutrophils and macrophages produce large amounts of ROS and RNS as part of the antimicrobial defense. Also, I...