U.S., Feb. 12 -- ClinicalTrials.gov registry received information related to the study (NCT07404358) titled 'Dalargin for Prevention of Organ Disfunction in High-Risk Abdominal Surgery' on Feb. 05.
Brief Summary: Major abdominal surgeries (e.g., gastrectomy, pancreatectomy, colectomy) carry a high risk of life-threatening postoperative complications, including multiorgan disfunction syndrome (MODS), acute kidney injur (AKI), miocardial injury after non-cardiac surgery (MINS) and severe infections. These complications are driven by ischemia-reperfusion injury, leading to oxidative stress and a systemic inflammatory response. Despite advances in surgical and anesthetic techniques, there are no effective pharmacological strategies for persona...