U.S., Nov. 27 -- ClinicalTrials.gov registry received information related to the study (NCT07251179) titled 'CHARACTERIZATION OF AUTOREACTIVE B LYMPHOCYTES IN AUTOIMMUNE DISEASES AND IMMUNE DEFICIENCIES' on Nov. 18.
Brief Summary: Autoimmune diseases (AID), whether systemic or organ-specific, affect approximately one in ten people, and their prevalence continues to increase. Many AIDs are linked to the emergence of autoreactive B cells (BCs) directed against components of the self. In healthy individuals, these autoreactive B cells are counter-selected or regulated before reaching the antibody-secreting cell compartment. However, in predisposed individuals, a breakdown in B cell tolerance can occur, leading to the formation of autoantibodi...