U.S., April 12 -- ClinicalTrials.gov registry received information related to the study (NCT06923709) titled 'Beneficial Effect of Amiloride on Progression of Chronic Kidney Disease' on April 02.
Brief Summary: This is a randomized, placebo-controlled, double-blinded crossover trial testing the effects of amiloride in patients with chronic kidney disease (CKD) and proteinuria.
In CKD with proteinuria, there is aberrant filtration of serine proteases and complement precursors into the tubular lumen. The interaction of these factors leads to proinflammatory complement activation, which may promote inflammation, opsonization, and formation of the membrane-attack complex, causing cell injury.
With the aim of preserving kidney function, reduc...