Clinical Trial: Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment Resistant Depression

U.S., July 24 -- ClinicalTrials.gov registry received information related to the study (NCT07080723) titled 'Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment Resistant Depression' on July 07.

Brief Summary: The trial utilizes a pragmatic, randomized, open label design with two parallel arms. Participants aged 18-65 with a diagnosis of unipolar depressive disorder and without stable remission in the past 12 months are randomized 1:1 to receive either algorithm guided treatment (AGT) or treatment as usual (TAU). The AGT approach incorporates pre-defined treatment steps, critical decision points, and "if-then" rules based on symptom response. It leverages prior treatment history, current symptomatology, a...