U.S., Jan. 8 -- ClinicalTrials.gov registry received information related to the study (NCT07322627) titled 'ALDH2 Single Nucleotide Polymorphisms and Prognosis of Esophageal Cancer Patients' on Dec. 22, 2025.
Brief Summary: Alcohol consumption, smoking, and betel nut chewing have been proven to be closely associated with the risk of esophageal cancer (EC). Recent studies have shown that alcohol-related detoxification genes in the ALDH family influence individual susceptibility to esophageal cancer. Aldehyde dehydrogenase 2 (ALDH2) is one of the most important enzymes in the ALDH family, involved in the metabolism of alcohol, acetaldehyde, and environmental aldehydes in the human body. We hypothesize that functional variations in ALDH2 may ...