U.S., Feb. 7 -- ClinicalTrials.gov registry received information related to the study (NCT07392723) titled 'ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults' on Oct. 20, 2025.
Brief Summary: This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults with mild cognitive impairment and APOE4 genotype. By targeting the endogenous synthesis of docosahexaenoic acid (DHA) through ALA supplementation, the investigators aim to overcome the limitations of direct DHA supplementation, particularly in APOE4 carriers who exhibit low brain DHA levels and...