U.S., Dec. 10 -- ClinicalTrials.gov registry received information related to the study (NCT07273279) titled 'ADH1B and ALDH Gene Variants and Lung Cancer Risk' on Nov. 26.
Brief Summary: Lung cancer in never-smokers is increasingly recognized as a disease influenced by genetic susceptibility. Aldehyde-metabolizing enzymes, including the ALDH gene family and ADH1B, play key roles in detoxifying reactive aldehydes that can damage DNA and promote oxidative stress. In this study, we will examine whether ten selected genetic variants, nine single nucleotide polymorphisms (SNPs) across five ALDH family genes and one variant in ADH1B are associated with the risk of lung cancer and its major subtypes. Limited epidemiological evidence is currently ...