Clinical Trial: ACEs, SIRT1, and Premature Vascular Aging in Humans

U.S., July 19 -- ClinicalTrials.gov registry received information related to the study (NCT07073352) titled 'ACEs, SIRT1, and Premature Vascular Aging in Humans' on June 30.

Brief Summary: Adverse childhood experiences (ACEs) are directly related to cardiovascular morbidity and mortality, and impaired vascular endothelial function (VEF) is an independent predictor of future cardiovascular disease (CVD) risk [1, 2]. Previous work from our lab (IRB 202010095) and others [3] demonstrates impaired VEF in young adults with prior exposure to ACEs even in the absence of clinical CVD risk factors. Sirtuin 1 (SIRT1) is a class III histone deacetylase (HDAC) that plays a role in regulating vascular homeostasis and reductions in SIRT1 are associated ...