U.S., Nov. 19 -- ClinicalTrials.gov registry received information related to the study (NCT07232459) titled '[18F]FT8 PET Imaging in Immunoglobulin Light Chain Amyloidosis' on Nov. 13.
Brief Summary: [18F]FT8, a derivative of 1-(4-pyridyl)-4-piperazinyl arene ([18F]TPZA), exhibits high affinity for AL amyloid in myocardial tissue sections and shows no significant binding to transthyretin amyloid. By comparing its diagnostic performance against established clinical methods, including echocardiography, contrast-enhanced MRI, and relevant laboratory tests, this study aims to establish [18F]FT8 as the basis for a robust PET protocol for the direct visualization and differential diagnosis of AL amyloidosis . The study preimarily evaluates the s...