New Delhi, Sept. 11 -- In a major breakthrough, researchers at the Indian Institute of Technology Kanpur (IIT Kanpur) have developed a novel antibody-based biosensor that can monitor the activation of G protein-coupled receptors (GPCRs) in live cells. GPCRs are the largest family of receptor proteins in human cells and are targeted by more than one-third of all clinically prescribed medicines.
Led by IIT Prof. Arun K Shukla, the research team has been investigating GPCR biology for over a decade. GPCRs, because of their central role, are considered some of the most important gateways for developing new drugs and therapies. The new biosensor represents a significant milestone in overcoming the technical challenges of monitoring receptor act...