Jammu, April 3 -- Anderson-Fabry disease (AFD) is a rare inherited condition that can impact multiple body organs. One system severely impacted is the kidneys, sometimes leading to end-stage kidney disease (ESKD). It is important to understand how this uncommon disease specifically influences the kidneys and causes ESKD. Catching it early through timely diagnosis and treatment helps patients effectively manage this genetic problem and maintain good quality of life.

AFD occurs due to shortage of an enzyme called alpha-galactosidase A. This leads to buildup of a fatty substance called globotriaosylceramide (Gb3) in cells across the body. Over time, this accumulation can damage kidneys and ultimately cause ESKD. In ESKD, the kidneys become ...