India, June 3 -- Johnson & Johnson (JNJ) Tuesday reported encouraging results from the Phase 3 AMPLITUDE study evaluating the combination of niraparib and abiraterone acetate (Akeega) plus prednisone in patients with metastatic castration-sensitive prostate cancer (mCSPC) with homologous recombination repair (HRR) genetic alterations including BRCA.
The study met its primary endpoint of radiographic progression-free survival (rPFS).
Results from the study showed that treatment with the niraparib combination reduced the risk of symptomatic progression by 56 percent in patients with BRCA mutations and 50 percent in patients with HRR mutations. This meant that patients experienced a longer delay in symptoms worsening and requiring radiation,...