India, Aug. 21 -- The major U.S. index futures are currently pointing to initial weakness on Wall Street on Thursday, with stocks likely to see further downside after ending the previous session off their worst levels but still mostly lower.

Lingering uncertainty about the outlook for interest rates may weigh on the markets ahead of Federal Reserve Chair Jerome Powell's highly anticipated speech at the Jackson Hole Economic Symposium on Friday.

Powell's remarks could have a significant impact on the outlook for rates ahead of the Fed's next monetary policy meeting in September.

"Powell is likely to keep his cards close to his vest, emphasize that the Fed cares very much about their dual mandate and explain that they are data dependent an...