India, June 24 -- Hoth Therapeutics (HOTH), Tuesday reported that its experimental topical gel, HT-001, achieved primary efficacy in at least one key dermatologic metric for 100 percent of patients in its Phase 2a CLEER-001 study addressing skin side effects from EGFR inhibitors.
EGFR inhibitors, used in cancers such as non-small cell lung and colorectal, often provoke painful rashes, itching, dryness, nail issues, and hair loss, leading many patients to reduce or halt therapy.
In CLEER-001, over 65% of participants experienced meaningful relief from pain and pruritus, and none required dose adjustments or treatment discontinuation. HT-001, applied once daily, leverages an FDA-approved neurokinin-1 receptor antagonist to dampen Substance ...