India, June 30 -- Biopharmaceutical company Amgen, Inc. (AMGN) announced Monday that the Phase 3 FORTITUDE-101 clinical trial evaluating first-line bemarituzumab plus chemotherapy (mFOLFOX6) met its primary endpoint of overall survival (OS) at a pre-specified interim analysis.
Bemarituzumab plus chemotherapy demonstrated a statistically significant and clinically meaningful improvement in OS as compared to placebo plus chemotherapy in people living with unresectable locally advanced or metastatic gastric or gastroesophageal junction (G/GEJ) cancer with FGFR2b overexpression and who are non-HER2 positive.
FGFR2b overexpression was defined as 2+/3+ staining in =10% of tumor cells by centrally performed immunohistochemistry (IHC) testing.
T...