India, Feb. 8 -- 4D Molecular Therapeutics (FDMT) announced positive initial interim 52-week data from the Phase 2b Population Extension cohort of the PRISM clinical trial evaluating 4D-150 in a broad wet age-related macular degeneration (wet AMD) patient population. Additional data were provided on the durability of aflibercept expression for up to two years.
The treatment with 3E10 vg/eye led to an impressive 83% reduction in injection burden compared to the projected on-label aflibercept 2 mg administered every eight weeks. Furthermore, 70% of patients required only 0-1 supplemental injection, and 57% remained injection-free through the 52-week period.
In the recently diagnosed subgroup, which most resembles the Phase 3 4FRONT-1 and 4F...