United Kingdom, April 19 -- Project Id: 126835
Description: Objective
The neocortex is densely innervated by neuromodulatory systems that act through the release of hormones, neuropeptides, and neurotransmitters such as histamine (HA), acetylcholine (ACh), noradrenaline (NA), dopamine (DA), and serotonin (5-HT), which modulate cortical function by diffusely targeting neurons and synapses in neural microcircuits. These neuromodulators regulate shifts between behavioral states such as sleep and wakefulness, or distraction and attention by controlling rhythmic network activity. It is thought that neuromodulators regulate rhythmic activity by controlling the intrinsic characteristics of neuronal networks across different organizational levels...