United Kingdom, March 19 -- Project Id: 125272
Description: Project description
Dissecting the mitochondrial quality control process
Mitochondria are key organelles in cellular homeostasis. They produce energy, regulate cell signalling and the biochemical reactions central to metabolism. To meet energy demands and retain their function, mitochondria communicate with the nucleus through a process known as the mitochondrial retrograde response (MRR) enacted by the nuclear transcription factors via mediators such as calcium ion (Ca2+), reactive oxygen species (ROS) and NAD/NADH ratio. The scope of the EU-funded FIRM project is to gain insight into the regulation of the MRR by informing the redistribution on the nucleus of the mitochondria a...