Netherlands, Feb. 18 -- Project Id: 124894
Description: Objective
The overall objective of EXPERT is to create an off-the-shelf mRNA-delivering nanomedicine platform that is manufactured via a quality-by-design (QbD) approach with precise nanoparticle characterization and specifications that meet the requirements for GMP scaling up and clinical translation. As proof-of-concept we will perform a first-in-man clinical study for an intratumorally administered immunostimulatory mRNA-nanomedicine in cancer patients. The work focuses on the three critical elements of the call "Innovation platforms for advanced therapies of the future" 1. EXPERT investigates mRNAs as therapeutics, which are classified as advanced therapies. 2. By showing proof-o...