Dissecting and Overcoming Innate Immune Barriers for Therapeutically Efficient Hematopoietic Stem Cell Gene Engineering

Italy, March 19 -- Project Id: 125270

Description: Project description

Paving the way for efficient haematopoietic stem cell modification

Gene transfer and editing technologies expose haematopoietic stem cells (HSC) to components recognisable by host antiviral factors that restrict their genetic engineering. The project team have identified an antiviral factor that blocks gene transfer in HSC and have discovered small molecules that counteract it. The EU-funded ImmunoStem project aims to identify the antiviral factors that prevent modifications of HSC, and the means to mitigate their effects. The project will build on the innovative concept that a better understanding of the crosstalk between HSC and viral vectors will uncover immune sen...