Discovery and characterization of food bioactive compounds modulating the Pentose Phosphate Pathway against non-alcoholic fatty liver disease.

Spain, Oct. 18 -- Project Id: 75650

Description: Grant agreement ID: 832741

Status

Ongoing project

Start date

1 October 2019

End date

30 September 2021

Funded under:

H2020-EU.1.3.2.

Overall budget:

€ 172 932,48

EU contribution

€ 172 932,48

Objective

Non-alcoholic fatty liver disease (NAFLD) affects 25% of adults, and at present there is no approved licensed medication. Oxidative stress has been recognised as an important factor in the pathological progression of NAFLD. Therefore, therapies to protect against liver redox imbalance in the progression of this disease are urgently needed. G6PD is the rate-limiting enzyme of the pentose phosphate pathway (PPP), providing the majority of the cellular NADPH necessary for...