Defining the antithrombin measurand: role of proteoforms in harmonisation of diagnostic tests in thrombosis

Netherlands, Dec. 6 -- Project Id: 77608

Description: Grant agreement ID: 843615

Status

Ongoing project

Start date

1 May 2019

End date

30 April 2021

Funded under:

H2020-EU.1.3.2.

Overall budget:

€ 187 572,48

EU contribution

€ 187 572,48

Objective

Current medical tests for antithrombin deficiency generally measure the overall activity, being blind for the actual proteoforms of AT that contribute to the test. To ensure accurate test results, a traceability chain needs to be in place, which requires the accurate definition of the exact analyte to be measured. I hypothesize that an in-depth understanding of the pathological molecular proteoforms of antithrombin (AT) will allow for the identification of clinically rele...